From musk to body odor: Decoding olfaction through genetic variation사향에서 신체 냄새로 : 유전자 변이를 통해 후각을 해독하는Research Article Published on 2022-02-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Amino acid amino acid substitutions androstenone Anosmia association Body odor change cis-3-hexen-1-ol coding contribute derived allele ENCODE example explicit functional Galaxolide Genetic genetic diversity Genetic variation Han Chinese human body Hypothesis implication IMPROVE individual information input intensity ionone mechanism musk novel association olfactory olfactory receptor OR4D6 OR51B2 OR5A1 OR7D4 Perception performed phenotype populations Previous studies provide receptor receptors reduced replicated reported robust second shown SNP SNPs trans Variation [DOI] 10.1371/journal.pgen.1009564 PMC 바로가기 [Article Type] Research Article
Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults조직 특이성 인식 TWAS(TSA-TWAS) 프레임워크는 HIV 양성 성인의 대사, 면역 및 바이러스 특성과의 새로운 연관성을 식별합니다.Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect affected AIDS analysis applied association associations assumption Bilirubin bioinformatics CETP cholesterol cholesteryl ester clinical complex contribute current dataset enzyme eQTLs error rate evaluate experimental design expressed expression expression quantitative trait loci False positive Gene Expression Genes greater group High-density lipoprotein High-density lipoprotein cholesterol highlighting identify Laboratory loci mechanisms methodology multiple tissues novel association plasma pleiotropic gene power previous study promote Protein provide Quantitative regulated Regulatory replicated Research robust specificity statistical tissue tissues total bilirubin total bilirubin levels traits transcriptional transcriptionally transcriptome-wide transfer Triglyceride type I type I error UGT1A1 uridine uridine diphosphate variety Viral Viral load [DOI] 10.1371/journal.pgen.1009464 PMC 바로가기 [Article Type] Research Article
Using machine learning of clinical data to diagnose COVID-19: a systematic review and meta-analysisResearch Article Published on 2020-09-292022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] COVID-19, [키워드] amplified Clinical data clinical variable clinical variables Cluster computational method correlation COVID-19 COVID-19 patient COVID-19 tests Critical dataset demonstrated diagnose Diagnosis diagnostic Diagnostic model Gender generate Healthcare system immune cells Influenza lack lymphocyte machine learning male Meta-analysis mitigate Neutrophils novel association pandemic Patient patient symptom patients reported symptoms Result sensitivity serum Serum level specificity Stress subgroups subtype Subtypes systematic review [DOI] 10.1186/s12911-020-01266-z PMC 바로가기 [Article Type] Research Article
Using machine learning of clinical data to diagnose COVID-19: a systematic review and meta-analysisResearch Article Published on 2020-09-292022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] Coronavirus, COVID-19, SARS, [키워드] amplified Clinical data clinical variable clinical variables Cluster computational method correlation COVID-19 COVID-19 patient COVID-19 tests Critical dataset demonstrated diagnose Diagnosis diagnostic Diagnostic model Gender generate Healthcare system immune cells Influenza lack lymphocyte machine learning male Meta-analysis mitigate Neutrophils novel association pandemic Patient patient symptom patients reported symptoms Result sensitivity serum Serum level specificity Stress subgroups subtype Subtypes systematic review [DOI] 10.1186/s12911-020-01266-z PMC 바로가기 [Article Type] Research Article
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach새로운 MMP12 유전자좌는 게놈 전체 발병 연령 정보 접근 방식을 사용하여 대동맥 죽상경화성 뇌졸중과 연관됩니다Research Article Published on 2014-07-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (atherosclerosis) affected affection age analyses Analysis analysis approach arteries Artery association associations Atherosclerosis atherosclerotic carotid carotid artery chromosome chromosome 11 Conditioning controls covariate demonstrated detect disease disease risk European evaluate Evidence evidence of examined explain Fold change fraction genetic association genetic associations genetic component Genetic predisposition Genetic variant Genome-wide association studies global healthcare GWAS heterogeneity identify IMPROVE increased risk independent information Informed investigated ischaemic stroke large artery lead loci locus Meta-analysis MMP12 mRNA expression novel novel association novel associations overexpressed performed phenotype phenotypic plaque plaques power prevalence rate prevalence rates Regression regression analysis Replication risk significantly small vessel SNP association SNP associations stroke subtype Subtypes the disease variant variants was performed [DOI] 10.1371/journal.pgen.1004469 PMC 바로가기 [Article Type] Research Article
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease대규모 유전자 중심 분석으로 관상동맥 질환에 대한 새로운 변종 식별Research Article Published on 2011-09-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABCG5 ABCG8 aetiology Affect allele Analysis array Artery Asians association association tests Author biochemical CAD candidate gene cardiovascular disease cellular characterized COL4A1 COL4A2 common variants complement conducted Control controls Coronary Coronary artery Coronary artery disease custom-designed array customised gene array CYP17A1 disease Effect European Europeans Evidence evidence of examined except for found Frequency function functional variant functional variants Gene Gene Expression Genes Genetic Genetic variant genome-wide association genotyped GWA heart disease help heterogeneity identify IL5 LIPA loci low frequency LPA majority mechanism not differ novel novel association novel associations Odds ratio Potential potential mechanism potential mechanisms replicate Replication reported risk risk factor South South Asian suggested supported susceptibility susceptibility loci target tested therapeutic interventions TRIB1 variant variants Vascular ZC3HC1 [DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article